Polysaccharides gums in drug delivery systems: A review

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Jindrayani Nyoo Putro, Felycia Edi Soetaredjo, Valentino Bervia Lunardi, Wenny Irawaty, Maria Yuliana, Shella Permatasari Santoso, Natania Puspitasari, I. Gede Wenten, Suryadi Ismadji

2023 International Journal of Biological Macromolecules Vol. 253 Review Cited by 56 Quartile

Abstract

For the drug delivery system, drug carriers' selection is critical to the drug's success in reaching the desired target. Drug carriers from natural biopolymers are preferred over synthetic materials due to their biocompatibility. The use of polysaccharide gums in the drug delivery system has received considerable attention in recent years. Polysaccharide gums are renewable resources and abundantly found in nature. They could be isolated from marine algae, microorganisms, and higher plants. In terms of carbohydrates, the gums are water-soluble, non-starch polysaccharides with high commercial value. Polysaccharide gums are widely used for controlled-release products, capsules, medicinal binders, wound healing agents, capsules, and tablet excipients. One of the essential applications of polysaccharide gum is drug delivery systems. The various kinds of polysaccharide gums obtained from different plants, marine algae, and microorganisms for the drug delivery system application are discussed comprehensively in this review paper. © 2023 Elsevier B.V.

Affiliations

Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Collaborative Research Center for Zero Waste and Sustainability, Jl. Kalijudan 37, East Java, Surabaya, 60114, Indonesia; Department of Chemical Engineering, Institute of Technology Bandung (ITB), Jl. Ganesha 10, Bandung, 40132, Indonesia