Shin-Ping Lin, Tsung-Kai Yi, Yi-Feng Kao, Ming-Chieh Tu, Chen-Che Hsieh, Szu Chuan Shen, Yu-Chieh Chou, Jheng-Jhe Lu, Shella Permatasari Santoso, Huey-Jine Chai, Kuan-Chen Cheng
In this study, we developed a dextran-modified foaming bacterial cellulose (FBC) hydrogel that utilized foam medium with dextran in situ. The resulting dextran/FBC hydrogel exhibited a high water content (92.3%–94.2%) and enhanced epithelial cell proliferation compared to unmodified FBC (79.1% vs. 68.4%). Furthermore, the combination of dextran/FBC with Botryocladia leptopoda extract (AE) further improved cell proliferation to 97.1%. In vivo wound-healing experiments in mice demonstrated that AE-loaded dextran/FBC achieved the most effective wound remodeling, with a normal epidermal thickness and regeneration of functional structures such as pores and hair follicles by day 12. This biomaterial can be directly produced from microbial biosynthesis with no post-modification. Its biodegradability, sustainable green production process, and great wound-remodeling capacity highlight its potential as a novel moist wound dressing. © 2026 Elsevier B.V.
School of Food Safety, Taipei Medical University, Taipei, 11042, Taiwan; Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan; Research Center of Biomedical Device, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan; Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung, 20246, Taiwan; Department of Seafood Science, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung, 81157, Taiwan; Graduate Programs of Nutrition Science, National Taiwan Normal University, Taipei, 11677, Taiwan; Institute of Biotechnology, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei, 10617, Taiwan; Department of Chemical Engineering, Faculty of Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Chemical Engineering Master Program, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Collaborative Research Center for Zero Waste and Sustainability, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Institute of Food Science and Technology, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei, 10617, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan; Department of Optometry, Asia University, 500 Lioufeng Rd., Wufeng, Taichung, 41354, Taiwan; Department of Food Science, Fu Jen Catholic University, 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei City, 242062, Taiwan