Jindrayani Nyoo Putro, Hana Fransisca Tulus, Christian Julius Wijaya, Dave Mangindaan, Wenny Irawaty, Chintya Gunarto, Nathania Puspitasari, Artik Elisa Angkawijaya, Astrid Rahmawati, Osamu Shimomura, Suryadi Ismadji
The use of natural-based polymer is currently limited due to its hydrophilic properties. This study investigates durian seed gum for applying a drug delivery system with the combination of chitosan as complex coacervate. The successful synthesis of durian seed gum–chitosan polyelectrolyte complex (PEC) occurred through the electrostatic interaction between gum and chitosan, confirmed by the FTIR spectra and H1 NMR of PEC. The analysis of Zeta Potential also showed the behavior of pH-responsive material, 3.42 mV in pH 2.0 and − 28.8 in pH 7.4. Other characterizations, such as SEM, TGA, DSC, and particle size analysis, were conducted to understand PEC’s characteristics further. The entrapment efficiency of dexamethasone using PEC was greater than 90%, with a high loading content of around 4 mg/gram PEC. The drug release profile from PEC follows the mechanism of polymer swelling and non-Fickian diffusion. The combination of durian seed gum and chitosan as a coacervate greatly enhances the controlled release of hydrophobic drugs. This suggests that durian seed gum–chitosan PEC has promising potential for use in pharmacokinetic research. © Qatar University and Springer Nature Switzerland AG 2024.
Chemical Engineering Master Program, Faculty of Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Collaborative Research Center for Sustainable and Zero Waste Industries, Jl. Kalijudan 37, Surabaya, East Java, 60114, Indonesia; Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Professional Engineer Program Department, Faculty of Engineering, Bina Nusantara University, K.H. Syahdan No. 9, Jakarta, 11480, Indonesia; Waste-Food-Environmental Nexus Research Interest Group, Bina Nusantara University, K.H. Syahdan No. 9, Jakarta, 11480, Indonesia; Plant Lipid Research Team, RIKEN Center for Sustainable Resource Science, Yokohama, 230- 0045, Japan; Department of Applied Chemistry, Osaka Institute of Technology, 5-16-1 Omiya, Ashahi-ku, Osaka, 535-8585, Japan