Yudhiakuari Sincihu, Mujib Hannan, Niluh Suwasanti, Laura Wihanto, Nita Kurniawati, Dewa Ayu Liona Dewi, Steven, Sianty Dewi, Ari Christy Mulyono, Irene Lingkan Parengkuan, Henry Ricardo Handoyo, F. X. Himawan Jong, Andre Young, Alvin Julian, Angeline Rivia Simanjuntak, Marion Florentia
Introduction: Plastic pollution is a current health problem. Micron-sized plastic particles (MPs) can harm health because they are accidentally consumed by living things and involved in the human food chain. Polyethylene was a plastic polymer that contaminates many human foods. The absorbed plastic particles will persistent and bioaccumulate in the blood. Thes e particles contain toxic ingredients that cause oxidation reactions in biological components, one of them is low-density lipoprotein (LDL). Ox-LDL causes damage to the nephron defenses, thereby triggering a damage cascade. Indicators of damage to kidney nephron function include serum albumin, blood urea nitrogen, and serum creatinine. Objective: Explain the mechanism of nephron function disorder due to consuming polyethylene MPs particles. Method: This research was a pure experimental study of 42 rats (Rattus norvegicus) which were randomly divided into 6 groups. The research design was a post-test only control group. The exposure dose was 0mg; 0.0375mg; 0.075mg; 0.15mg, 0.3mg, 0.6mg MPs particles per day were administered sequentially to each group. MPs particles were given using an oral probe for 90 days. The data was analyzed using the Smart-PLS program to create a mechanism model for nephron function disorder due to consuming MPs particles. Result: Oral exposure to MPs particles in rats model significantly increased blood levels of MPs particles and blood Ox-LDL. The presence of MPs particles in the blood will also increase blood Ox-LDL, even reduce serum albumin levels, increase blood urea nitrogen levels and serum creatinine levels. Meanwhile, increasing Ox-LDL only contributed to a decrease in serum albumin levels and an increase in blood urea nitrogen levels (all T-stat values > 1.96). Conclusion: Consuming MPs particles can disrupt nephron function in rats. © 2024, Muhammadiyah Palu University. All rights reserved.
Fakultas Kedokteran, Universitas Katolik Widya Mandala, Surabaya, Indonesia; Universitas Wiraraja, Indonesia