Felycia Edi Soetaredjo, Suryadi Ismadji, Shella Permatasari Santoso, Jindrayani Nyoo Putro, Kuncoro Foe, Gladdy L. Waworuntu
In contemporary society, inflammatory bowel disease (IBD) is prevalent and acknowledged. In treating inflammatory bowel disease (IBD), pH-sensitive drug delivery systems are commonly utilized. Nonetheless, their efficacy tends to be reduced as a result of modifications in the pH levels within the intestines. This study aims to develop a medication delivery system responsive to changes in pH to deliver 5-aminosalicylic acid specifically to the colon. CNC-chitosan hydrogel was produced by implementing the cross-linking technique, employing glutaraldehyde as the cross-linking agent. The hydrogel was subjected to characterization using scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling capacity analysis, and Fourier-transform infrared spectroscopy (FTIR). The release kinetics of 5-aminosalicylic acid from cellulose nanocrystals (CNC) and CNC-chitosan composites showed superior performance at pH 7.4 compared to pH 2.4. The release profile of 5-aminosalicylic acid from CNC-chitosan hydrogel can be accurately represented by the Korsemeyar-Peppas equation. CNC and CNC-chitosan were compatible with osteoblast cells, indicating their lack of toxicity. © 2024 by the authors.
Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Indonesia; Collaborative Research Center for Zero Waste and Sustainability, Jl. Kalijudan 37, East Java, Surabaya, 60114, Indonesia; Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Kalisari Selatan No.1 Kalisari, Surabaya, 60112, Indonesia; Faculty of Medicine, Widya Mandala Surabaya Catholic University, Kalisari Selatan No.1 Kalisari, Surabaya, 60112, Indonesia