Jindrayani Nyoo Putro, Suryadi Ismadji, Chintya Gunarto, Maria Yuliana, Shella Permatasari Santoso, Felycia Edi Soetaredjo, Yi Hsu Ju
The Nanocrystalline cellulose (NCC) was prepared from filter paper by acid hydrolysis process. The modification of NCC with cationic, anionic, and nonionic surfactant did not have a tremendous effect on the chemical structure of material based on the characterization of XRD and FTIR. The modified NCCs were employed as a drug carrier for paclitaxel (PTX). Increasing concentration of ionic surfactants can enhance the loading of the hydrophobic drug, while the opposite trend was observed for nonionic surfactant modified nanocrystals. The attachment of surfactant toward the particle was a more likely physical aggregation of micelle on the surface of nanocrystals. Larger particle size was observed after the modification of nanocrystal cellulose. The fitting of Higuchi and sigmoidal models were applied in the release profile to investigate the kinetic release mechanism of paclitaxel at pH 5.8 and 7.4. Cell viability was determined to check the biocompatibility of the materials toward mouse osteoblast cells 7F2 using MTT assay. Toxic behavior was not observed for NCC, while CTAB was completely not compatible with cells. © 2019 Elsevier B.V.
Department of Chemical Engineering, National Taiwan University of Science and Technology, No. 43, Sec 4, Keelung Rd, Taipei, 10607, Taiwan; Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, No. 43, Sec 4, Keelung Rd, Taipei, 10607, Taiwan