Jindrayani Nyoo Putro, Valentino Bervia Lunardi, Felycia Edi Soetaredjo, Maria Yuliana, Shella Permatasari Santoso, I. Gede Wenten, Suryadi Ismadji
The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Chemical Engineering Department, Institut Teknologi Bandung, Jalan Ganesa No. 10, Bandung, 40132, Indonesia; Research Center for Nanosciences and Nanotechnology, Institute Teknologi Bandung, Jalan Ganesa No. 10, Bandung, 40132, Indonesia