Elok Zubaidah, Ike Susanti, Sudarminto Setyo Yuwono, Aldila Putri Rahayu, Ignatius Srianta, Ihab Tewfik
This study investigated the combined impact of sauerkraut and Leuconostoc mesenteroides culture on immunomodulatory activity in experimental animal. The in vivo immunomodulatory activity of Escherichia coli-infected Balb-C mice was ascertained in fermented sauerkrauts [test vs. control]. Both sauerkrauts enhanced the adaptive immune response [evidenced by an increase in CD4+ CD8+ IFN-γ, TNFα] and innate immune response [represented by a decrease of CD68-IL-6]. Nevertheless, the in vivo immunomodulatory activity of sauerkraut combined with L. mesenteroides was higher than that shown in sauerkraut control solely. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Jalan Veteran, Malang, 65145, Indonesia; Department of Agronomy, Faculty of Agriculture, Brawijaya University, Malang, 65145, Indonesia; Department of Food Technology, Faculty of Agricultural Technology, Widya Mandala Catholic University Surabaya, Jalan Dinoyo 42-44, Surabaya, 60265, Indonesia; School of Life Sciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, United Kingdom