Sandy Budi Hartono, Lannie Hadisoewignyo, Yanan Yang, Anand Kumar Meka, Antaresti, Chengzhong Yu
In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of 'free curcumin'. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route. © 2016 IOP Publishing Ltd.
Department of Chemical Engineering, Widya Mandala Catholic University, Surabaya, Indonesia; Faculty of Pharmacy, Widya Mandala Catholic University, Surabaya, Indonesia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, QLD, Australia