Elok Zubaidah, Chairul Anam Afgani, Umi Kalsum, Ignatius Srianta, Philippe J. Blanc
The research compared antidiabetic activity of snake fruit Kombucha, black tea Kombucha and metformin in streptozotocin-induced diabetic rats. Snake fruit Kombucha, black tea Kombucha and metformin were orally administered to the diabetic rats daily during a 28-day experiment. Fasting plasma glucose (FPG) levels, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and lipid profiles (total triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol) of the blood plasma were investigated. Pancreas immunohistochemical study and β-cells quantification were also conducted. The products significantly (p < 0.05) reduced fasting plasma glucose levels (67–76%) and improved oxidative stress indices and lipid profiles. From immunohistochemical staining of pancreatic tissues, pancreatic β-cells were also improved in the diabetic rats by the products. The snake fruit Kombucha compared with the metformin but better than the black tea Kombucha as a diabetes therapy agent. © 2019
Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Jalan Veteran Malang, 65145, Indonesia; Department of Pharmacology, Faculty of Medicine, Brawijaya University, Jalan Veteran Malang, 65145, Indonesia; Department of Food Technology, Faculty of Agricultural Technology, Widya Mandala Catholic University Surabaya, Jalan Dinoyo 42-44, Surabaya, 60265, Indonesia; Université de Toulouse, INSA, LISBP, CNRS, UMR5504, INRA, UMR792, Ingénierie des Systèmes Biologiques et des Procédés, 135 Avenue de Rangueil, Toulouse, F-31077, France