Jindrayani Nyoo Putro, Suryadi Ismadji, Chintya Gunarto, Felycia Edi Soetaredjo, Yi Hsu Ju
Starch nanoparticles were prepared from native potato starch using acid hydrolysis and precipitation methods. The acid hydrolysis method yielded high relative crystallinity of starch nanoparticles (SNP-H), while ethanol precipitation method resulted in nanoparticles (SNP-P) with low crystallinity, which shows a broad peak in diffractogram. SNP-P has higher drug loading capacity than SNP-H. The modification of nanoparticles using CTAB resulted in the highest drug loading compared to SDS and Tween 20. A sustained release mechanism at pH 5.8 and 7.4 was observed for SNP-H. Anionic surfactant modified SNP shows the burst release in the initial time of drug release. The cumulative release is lower at pH 5.8 than pH 7.4. The simple sigmoidal function and Higuchi model were used to represent the kinetic release profile of Paclitaxel from starch nanoparticles. Cytotoxicity assay of the original nanoparticles showed good biocompatibility of nanoparticles with 7F2 cells. © 2019 Elsevier B.V.
Department of Chemical Engineering, National Taiwan University of Science and Technology, No. 43, Sec 4, Keelung Rd, Taipei, 10607, Taiwan; Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya, 60114, Indonesia; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, No. 43, Sec 4, Keelung Rd, Taipei, 10607, Taiwan